3-Mercaptopicolinic acid hydrochloride

Cat. No. 7577 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Phospoenolpyruvate carboxykinase (PEPCK) inhibitor; inhibits gluconeogenesis

化学名： 3-Mercapto-2-pyridinecarboxylic acid hydrochloride

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 3-Mercaptopicolinic acid hydrochloride

3-Mercaptopicolinic acid hydrochloride is a phospoenolpyruvate carboxykinase (PEPCK) inhibitor (IC₅₀ = 7.5 μM at hPEPCK). Inhibits glucose synthesis. In vitro, 3-Mercaptopicolinic acid reduces proliferation of T_reg cells, induces myogenic differentiation of C2C12 cells, and reduces colony growth formation of MCF7 cells. Also sensitizes melanoma cells to Vemurafenib (Cat. No. 7309) via inhibition of cytoplasmic PEPCK.

技术数据 for 3-Mercaptopicolinic acid hydrochloride

分子量	191.63
公式	C₆H₅NO₂S.HCl
储存	Store at -20°C
CAS Number	320386-54-7
PubChem ID	24721311
InChI Key	DYGYEUUVNLEHJP-UHFFFAOYSA-N
Smiles	O=C(C1=NC=CC=C1S)O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 3-Mercaptopicolinic acid hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	3.83	20
	water	1.92	10

制备储备液 for 3-Mercaptopicolinic acid hydrochloride

以下数据基于产品分子量 191.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	26.09 mL	130.46 mL	260.92 mL
1 mM	5.22 mL	26.09 mL	52.18 mL
2 mM	2.61 mL	13.05 mL	26.09 mL
10 mM	0.52 mL	2.61 mL	5.22 mL

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产品说明书 for 3-Mercaptopicolinic acid hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 3-Mercaptopicolinic acid hydrochloride

参考文献是支持产品生物活性的出版物。

Watson et al (2021) Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature 591 645 PMID: 33589820

Mcleod et al (2019) Characterization of 3-[(carboxymethyl)thio]picolinic acid: a novel inhibitor of phosphoenolpyruvate carboxykinase. Biochemistry 58 3918 PMID: 31461616

Brearley et al (2020) The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Sci.Rep. 10 22177 PMID: 33335245

Aragó et al (2020) Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M. Biomed.Pharmacother. 121 109601 PMID: 31739159

Ren et al (2022) Overcoming chemoresistance to b-raf inhibitor in melanoma via targeted inhibition of phosphoenolpyruvate carboxykinase1 using 3-mercaptopropionic acid. Bioengineered 13 13571

If you know of a relevant reference for 3-Mercaptopicolinic acid hydrochloride, please let us know.

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