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3-MPPI

Cat. No. 0581 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0581 has been discontinued.

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说明： α1 ligand
化学名： 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for 3-MPPI

Very potent ligand for α1 sites (Ki for displacement of prazosin = 0.2 nM). Displays different binding properties for each α1 subtype (pKi values are 8.74, 9.44 and 9.57 for α1B, α1D and α1A adrenoceptors respectively). Also binds to 5-HT1A sites (Ki = 50 nM).

技术数据 for 3-MPPI

分子量 419.48
公式 C23H25N5O3
储存 Store at RT
CAS Number 133399-65-2
PubChem ID 4013695
InChI Key AQASGOHUMGAWJJ-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)N1CCN(CCN2C(=O)NC3=C(NC4=CC=CC=C34)C2=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 3-MPPI

分析证书目前不在网上提供。
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化学品安全技术说明书

参考文献 for 3-MPPI

参考文献是支持产品生物活性的出版物。

Russo et al (1991) Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands. J.Med.Chem. 34 1850 PMID: 1648138

Romeo et al (2003) New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes. J.Med.Chem. 46 2877 PMID: 12825930

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关键词: 3-MPPI, 3-MPPI supplier, 5-HT1A, ligand, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, Serotonin, Receptors, 5-HT1, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Adrenergic, Alpha-1, 0581, Tocris Bioscience

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.