4-Acetyl-1,1-dimethylpiperazinium iodide

Discontinued Product

0352 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.
说明: nAChR agonist
说明书
引用文献
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文献 (1)

生物活性

4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.

技术数据

分子量 284.14
公式 C8H17IN2O
储存 Store at RT
CAS Number 75667-84-4
PubChem ID 5311072
InChI Key VXBLRKDEHGKPAC-UHFFFAOYSA-M
Smiles C[N+]1(C)CCN(CC1)C(=O)C.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献

参考文献是支持产品生物活性的出版物。

Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177 PMID: 2747625

Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127 PMID: 3485051

Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289

关键词: 4-Acetyl-1,1-dimethylpiperazinium iodide, 4-Acetyl-1,1-dimethylpiperazinium iodide supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, (Non-selective), 0352, Tocris Bioscience

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该领域的文献

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.