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4-DAMP

Cat. No. 0482 16 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Muscarinic M3 antagonist
化学名： 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
纯度： ≥99% (HPLC)
说明书
引用文献 (16)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 4-DAMP

4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.

技术数据 for 4-DAMP

分子量 451.33
公式 C21H26INO2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1952-15-4
PubChem ID 3014059
InChI Key WWJHRSCUAQPFQO-UHFFFAOYSA-M
Smiles [I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4-DAMP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.28 25

制备储备液 for 4-DAMP

以下数据基于产品分子量 451.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 8.86 mL 44.31 mL 88.63 mL
1.25 mM 1.77 mL 8.86 mL 17.73 mL
2.5 mM 0.89 mL 4.43 mL 8.86 mL
12.5 mM 0.18 mL 0.89 mL 1.77 mL

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参考文献 for 4-DAMP

参考文献是支持产品生物活性的出版物。

Barlow and Shepherd (1986) A further search for selective antagonists at M2- muscarinic receptors. Br.J.Pharmacol. 89 837 PMID: 3814912

Michel et al (1989) Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP. Eur.J.Pharmacol. 166 459 PMID: 2806372

If you know of a relevant reference for 4-DAMP, please let us know.

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关键词: 4-DAMP, 4-DAMP supplier, Muscarinic, M3, antagonists, Receptors, Acetylcholine, Ach, 0482, Tocris Bioscience

16 篇 4-DAMP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4-DAMP 的部分引用包括：

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449 PMID: 25158854

Placeres-Uray et al (2014) M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J 6 22 PMID: 24377382

Pacini et al (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 15 1489 PMID: 25482946

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388 PMID: 25143547

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773

Kitazawa et al (2009) M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. Mol Pharmacol 330 487 PMID: 19429792

Wallace et al (2015) Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Microvasc Res 3 PMID: 26359240

Chen et al (2012) Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem 287 5059 PMID: 22184108

Emmerson et al (2017) SOX2 regulates acinar cell development in the salivary gland. Elife 6 PMID: 28623666

Matsumoto et al (2010) Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats. Urology 75 862 PMID: 20156651

Hodges et al (2012) Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res 103 99 PMID: 22975404

Kajiya et al (2012) Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. J Neurosci 82 115 PMID: 22511543

Fonseca et al (2015) Diadenosine tetraphosphate contributes to CB-induced tear secretion. Purinergic Signal 11 87 PMID: 25398705

Howell et al (2005) In vivo antimuscarinic actions of the third generation antihistaminergic agent, deslorat. BMC Pharmacol 5 13 PMID: 16109168

Clancy et al (2007) Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. Physiol Rep 27 6388 PMID: 17567799

Solanki et al (2007) Cholinergic innervation of the guinea-pig isolated vas deferens. Naunyn Schmiedebergs Arch Pharmacol 376 265 PMID: 17992517

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