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Discontinued Product
0748 has been discontinued.
说明： σ ligand, σ1> σ2
化学名： N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
纯度： ≥99% (HPLC)
生物活性 for 4-IBP
Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.
技术数据 for 4-IBP
| 分子量 | 420.29 |
| 公式 | C19H21IN2O |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 155798-08-6 |
| PubChem ID | 132995 |
| InChI Key | HELCSESNNDZLFM-UHFFFAOYSA-N |
| Smiles | IC1=CC=C(C=C1)C(=O)NC1CCN(CC2=CC=CC=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 4-IBP
参考文献 for 4-IBP
参考文献是支持产品生物活性的出版物。
Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691 PMID: 11588125
John et al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737 PMID: 8021913
Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571
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关键词: 4-IBP, 4-IBP supplier, ligand, σ1, sigma1, σ2, sigma2, receptors, Sigma1, Receptors, 0748, Tocris Bioscience
2 篇 4-IBP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4-IBP 的部分引用包括：
Rodríguez-Muñoz et al (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain 11 51 PMID: 30223868
Amer et al (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol 168 1445 PMID: 23121507
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