4-Methylhistamine dihydrochloride

Cat. No. 2342 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective, high affinity H₄ agonist

化学名： 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride is a potent, high affinity H₄ receptor agonist (K_i = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

技术数据 for 4-Methylhistamine dihydrochloride

分子量	198.09
公式	C₆H₁₁N₃.2HCl
储存	Desiccate at RT
CAS Number	36376-47-3
PubChem ID	215819
InChI Key	BVJIXYJOFWYOBL-UHFFFAOYSA-N
Smiles	Cl.Cl.CC1=C(CCN)NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4-Methylhistamine dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	246.8	50

制备储备液 for 4-Methylhistamine dihydrochloride

以下数据基于产品分子量 198.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	10.1 mL	50.48 mL	100.96 mL
2.5 mM	2.02 mL	10.1 mL	20.19 mL
5 mM	1.01 mL	5.05 mL	10.1 mL
25 mM	0.2 mL	1.01 mL	2.02 mL

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产品说明书 for 4-Methylhistamine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 4-Methylhistamine dihydrochloride

参考文献是支持产品生物活性的出版物。

Lim et al (2005) Evaluation of histamine H₁-, H₂-, and H₃-receptor ligands at the human histamine H₄ receptor: identification of 4-methylhistamine as the first potent and selective H₄ receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036

Gbahou et al (2006) Compared pharmacology of human histamine H₃ and H₄ receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74

If you know of a relevant reference for 4-Methylhistamine dihydrochloride, please let us know.

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关键词: 4-Methylhistamine dihydrochloride, 4-Methylhistamine dihydrochloride supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, 2342, Tocris Bioscience

4 篇 4-Methylhistamine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4-Methylhistamine dihydrochloride 的部分引用包括：

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168

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