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说明： Inhibits eIF4F subunit interaction; inhibits protein translation
化学名： 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for 4E1RCat
4E1RCat is an inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
技术数据 for 4E1RCat
| 分子量 | 478.45 |
| 公式 | C28H18N2O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 328998-25-0 |
| PubChem ID | 16195554 |
| InChI Key | BBQRBOIMSKMFFO-LTGZKZEYSA-N |
| Smiles | O=C1N(C3=CC=C(C(O)=O)C=C3)C(C4=CC=CC=C4)=C/C1=C\C2=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 4E1RCat
参考文献 for 4E1RCat
参考文献是支持产品生物活性的出版物。
Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046
关键词: 4E1RCat, 4E1RCat supplier, eIF4F, inhibitors, inhibits, protein, synthesis, chemosensitizing, chemosensitizer, cap, dependent, translation, eIF4E, eIF4G, 4E-BP1, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4215, Tocris Bioscience
1 篇 4E1RCat 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4E1RCat 的部分引用包括：
Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284 PMID: 25062042
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