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说明： Inhibits eIF4E:eIF4G subunit interaction
化学名： α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid
纯度： ≥98% (HPLC)
生物活性 for 4EGI-1
4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.
技术数据 for 4EGI-1
| 分子量 | 451.28 |
| 公式 | C18H12Cl2N4O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315706-13-9 |
| PubChem ID | 6911989 |
| InChI Key | KFRKRECSIYXARE-HMAPJEAMSA-N |
| Smiles | OC(=O)C(\CC1=CC=CC=C1[N+]([O-])=O)=N/NC1=NC(=CS1)C1=CC(Cl)=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 4EGI-1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.13 | 100 |
制备储备液 for 4EGI-1
以下数据基于产品分子量 451.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.08 mL | 22.16 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for 4EGI-1
参考文献 for 4EGI-1
参考文献是支持产品生物活性的出版物。
Gkogkas et al (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 371 PMID: 23172145
Moerke et al (2007) Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 257 PMID: 17254965
If you know of a relevant reference for 4EGI-1, please let us know.
关键词: 4EGI-1, 4EGI-1 supplier, eIF4E, eIF4G, inhibitors, inhibits, interaction, cap-dependent, translation, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4800, Tocris Bioscience
5 篇 4EGI-1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4EGI-1 的部分引用包括：
Lei et al (2020) CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation. Neuron 105 475-490.e6 PMID: 31780330
Riz et al (2016) Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget 7 66360 PMID: 27626179
Christian et al (2022) High-throughput translational profiling with riboPLATE-seq. Sci Rep 12 5718 PMID: 35383235
Rolf et al (2018) The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling. Cell Metab 28 895-906.e5 PMID: 30197303
Michelle et al (2017) Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS One 12 e0177054 PMID: 28486555
您是否知道使用了 Tocris 4EGI-1 的优秀论文？ 请告知我们.
4EGI-1 的评论
平均评分: 4 (Based on 1 Review.)
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(4EGI-1, 50 µM).
By
Anonymous on 12/11/2019
分析类型： In Vitro
种属： Human
细胞系/组织： LP-1 cell line
Cells were treated with MG-132 (15 µM) for 18 hours in the absence or presence of an eIF4E/eIF4G interaction inhibitor (4EGI-1, 50 µM) or an MNK inhibitor (CGP57380, 10 μM).
