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4F 4PP oxalate

Cat. No. 0523 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective 5-HT2A antagonist
化学名： 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 4F 4PP oxalate

4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as Ketanserin (Cat. No. 0908) but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).

技术数据 for 4F 4PP oxalate

分子量 429.49
公式 C22H26FNO.C2H2O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 144734-36-1
PubChem ID 24745966
InChI Key VUJYJCRJPFMHEM-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCCCC2=CC=CC=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 4F 4PP oxalate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 20

制备储备液 for 4F 4PP oxalate

以下数据基于产品分子量 429.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for 4F 4PP oxalate

参考文献是支持产品生物活性的出版物。

Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153 PMID: 9542727

Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903 PMID: 1479590

If you know of a relevant reference for 4F 4PP oxalate, please let us know.

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关键词: 4F 4PP oxalate, 4F 4PP oxalate supplier, Selective, 5-HT2A, antagonists, Serotonin, Receptors, 5-HT2, 4F4PP, oxalate, 0523, Tocris Bioscience

3 篇 4F 4PP oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 4F 4PP oxalate 的部分引用包括：

Lee et al (2018) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol 142 1349 PMID: 29920354

Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

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