主页 / Product Type / PROTAC® Degraders & Targeted Protein Degradation / Degrader Building Blocks / Functionalized E3 Ligase Ligands / 5-Amino-Thalidomide

5-Amino-Thalidomide

Cat. No. 7678 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cereblon ligand with amine on C5 for onward chemistry
化学名： 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
纯度： ≥95% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for 5-Amino-Thalidomide

5-Amino-Thalidomide is a functionalized cereblon (CRBN) ligand for PROTAC® research and development; incorporates an E3 ligase ligand with an amine on the C5 position of the phthalimide ring for onward chemistry to generate Protein Degraders with rigid linkers. Degraders with modifications on the C5 position reduce off-target zinc-finger proteins degradation.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for 5-Amino-Thalidomide

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for 5-Amino-Thalidomide

分子量 273.24
公式 C13H11N3O4
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 191732-76-0
InChI Key IICWMVJMJVXCLY-UHFFFAOYSA-N
Smiles O=C1C2=CC=C(N)C=C2C(=O)N1C3C(=O)NC(=O)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 5-Amino-Thalidomide

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 5-Amino-Thalidomide

参考文献是支持产品生物活性的出版物。

Nguyen et al (2021) Proteolysis Targeting Chimeras With Reduced Off-targets. bioRxiv

If you know of a relevant reference for 5-Amino-Thalidomide, please let us know.

按标靶查看相关产品

关键词: 5-Amino-Thalidomide, 5-Amino-Thalidomide supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, amine, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, CRBN, rigid, linker, semi-rigid, cross-linker, rigidity, Functionalized, Ligase, Ligands, 7678, Tocris Bioscience

篇 5-Amino-Thalidomide 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 5-Amino-Thalidomide 的引用文献。 您是否知道使用了 Tocris 5-Amino-Thalidomide 的优秀论文？ 请告知我们.

5-Amino-Thalidomide 的评论

目前没有该产品的评论。 Be the first to review 5-Amino-Thalidomide and earn rewards!

Have you used 5-Amino-Thalidomide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia