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Submit Review5-Carboxamidotryptamine maleate
说明： 5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7
别名： AH-21467,5-CT
纯度： ≥99% (HPLC)
生物活性 for 5-Carboxamidotryptamine maleate
5-Carboxamidotryptamine maleate is a 5-HT1 agonist with high affinity at 5-HT1A, 5-HT1B, 5-HT1D, 5-ht5 and 5-HT7 receptors.
技术数据 for 5-Carboxamidotryptamine maleate
| 分子量 | 319.32 |
| 公式 | C11H13N3O.C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 74885-72-6 |
| PubChem ID | 11709509 |
| InChI Key | PZQZSWAOVAMBQM-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.NCCC1=CNC2=CC=C(C=C12)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 5-Carboxamidotryptamine maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.93 | 100 |
制备储备液 for 5-Carboxamidotryptamine maleate
以下数据基于产品分子量 319.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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产品说明书 for 5-Carboxamidotryptamine maleate
参考文献 for 5-Carboxamidotryptamine maleate
参考文献是支持产品生物活性的出版物。
Beer et al (1992) An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatr. in the central nervous system of seven species. Eur.J.Pharmacol. 213 193 PMID: 1325915
Nowak et al (1993) [3H]-5-carboxamidotryptamine labels 5HT1D binding sites in bovine substantia nigra. Br.J.Pharmacol. 109 1206 PMID: 8401931
Zifa and Fillion (1992) 5-Hydroxytryptamine receptors. Pharmacol.Rev. 44 401 PMID: 1359584
Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046
If you know of a relevant reference for 5-Carboxamidotryptamine maleate, please let us know.
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关键词: 5-Carboxamidotryptamine maleate, 5-Carboxamidotryptamine maleate supplier, high, affinity, 5ht5A, 5-HT7, 5-HT1, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, 5-ht5, Non-Selective, AH21467, AH-21467, 5-CT, Non-selective, 0458, Tocris Bioscience
14 篇 5-Carboxamidotryptamine maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 5-Carboxamidotryptamine maleate 的部分引用包括：
Kim et al (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Neuron 190 4795 PMID: 23554310
Gantz et al (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Am J Physiol Renal Physiol 78 807 PMID: 23764286
Chien and Su (2015) 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts. PLoS One 22 42 PMID: 26076928
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589 PMID: 19651659
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285
Bijata et al (2017) Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix Cell Rep 19 1767 PMID: 28564597
Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. Br J Pharmacol 10 e0140369 PMID: 26460748
Sargin et al (2016) Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels Elife 5 e21416 PMID: 27874831
Chan et al (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog 12 e1005651 PMID: 27187180
Maclean and Morecroft (2001) Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy. Br J Pharmacol 134 614 PMID: 11588116
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. J Immunol 128 730 PMID: 10516655
Seeburg et al (2004) Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci 24 10950 PMID: 15574745
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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