5-Iodo-A-85380 dihydrochloride

Name: 5-Iodo-A-85380 dihydrochloride
Brand: Tocris Bioscience
SKU: 1518

Cat. No. 1518 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1518 has been discontinued.

说明： High affinity α4β2 and α6β2 subtype-selective nAChR agonist

化学名： 3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridine dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

文献 (2)

生物活性技术数据说明书参考文献

生物活性 for 5-Iodo-A-85380 dihydrochloride

5-Iodo-A-85380 dihydrochloride is a a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors. Activates α-CTx-MII-sensitive and -insensitive components of [³H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC₅₀ values are 12.7 and ~35 nM respectively). ~5000-, 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively.

Precursor also available.

技术数据 for 5-Iodo-A-85380 dihydrochloride

分子量	363.03
公式	C₉H₁₁IN₂O.2HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	1217837-17-6
PubChem ID	54758463
InChI Key	ZJVVFYWEBSHGBV-JZGIKJSDSA-N
Smiles	IC1=CN=CC(OC[C@@H]2CCN2)=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 5-Iodo-A-85380 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 5-Iodo-A-85380 dihydrochloride

参考文献是支持产品生物活性的出版物。

Koren et al (1998) 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J.Med.Chem. 41 3690 PMID: 9733494

Mogg et al (2004) Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47 848 PMID: 15527819

Mukhin et al (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol.Pharmacol. 57 642 PMID: 10692507

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关键词: 5-Iodo-A-85380 dihydrochloride, 5-Iodo-A-85380 dihydrochloride supplier, High, affinity, α4β2, a4b2, α6β2, alpha6beta2, a6b2, subtype-selective, agonists, nicotinic, Receptors, Acetylcholine, nAChR, Non-Selective, Subtypes, Other, 5IA85380, Nicotinic, (Other, Subtypes), (a4b2), 1518, Tocris Bioscience

3 篇 5-Iodo-A-85380 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 5-Iodo-A-85380 dihydrochloride 的部分引用包括：

Hamouda et al (2009) Photoaffinity labeling the agonist binding domain of alpha4beta4 and alpha4beta2 neuronal nicotinic acetylcholine receptors with [(125)I]epibatidine and 5[(125)I]A-85380. Biochim Biophys Acta 1788 1987 PMID: 19545536

Chatzidaki et al (2015) Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. Neurochem Res 10 e0125116 PMID: 25906356

Brown and Wonnacott (2015) Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors. Pharmacol Res Perspect 40 2047 PMID: 24728867

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