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5J 4

Cat. No. 5490 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： CRAC channel blocker; anti-inflammatory
化学名： N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 5J 4

5J 4 is a calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

技术数据 for 5J 4

分子量 312.34
公式 C16H12N2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 827001-82-1
PubChem ID 2968289
InChI Key WMUSJLJASFXGHN-UHFFFAOYSA-N
Smiles OC1=CC2=C(C=C1)C(NC(NC(C3=CC=CO3)=O)=S)=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 5J 4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.23 100
ethanol 3.12 10

制备储备液 for 5J 4

以下数据基于产品分子量 312.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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参考文献 for 5J 4

参考文献是支持产品生物活性的出版物。

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID: 24307733

If you know of a relevant reference for 5J 4, please let us know.

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关键词: 5J 4, 5J 4 supplier, 5J4, CRAC, calcium, release, activated, store, operated, entry, SOCE, anti-inflammatory, channels, Ca2+, blockers, Other, Calcium, Channels, STIM-Orai, 5490, Tocris Bioscience

1 篇 5J 4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 5J 4 的部分引用包括：

Rao et al (2016) Homer1a attenuates glutamate-induced oxidative injury in HT-22 cells through regulation of store-operated calcium entry. Sci Rep 6 33975 PMID: 27681296

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