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6,8-Bis(benzylthio)octanoic acid

Cat. No. 5348 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PDH and KGDH inhibitor
化学名： 6,8-Bis[(phenylmethyl)thio]octanoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 6,8-Bis(benzylthio)octanoic acid

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

技术数据 for 6,8-Bis(benzylthio)octanoic acid

分子量 388.59
公式 C22H28O2S2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 95809-78-2
PubChem ID 24770514
InChI Key ZYRLHJIMTROTBO-UHFFFAOYSA-N
Smiles OC(CCCCC(SCC2=CC=CC=C2)CCSCC1=CC=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 6,8-Bis(benzylthio)octanoic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.86 100
ethanol 38.86 100

制备储备液 for 6,8-Bis(benzylthio)octanoic acid

以下数据基于产品分子量 388.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.87 mL 25.73 mL
5 mM 0.51 mL 2.57 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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产品说明书 for 6,8-Bis(benzylthio)octanoic acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 6,8-Bis(benzylthio)octanoic acid

参考文献是支持产品生物活性的出版物。

Zachar et al (2011) Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J.Mol.Med. (Berl.) 89 1137 PMID: 21769686

Stuart et al (2014) A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2 4 PMID: 24612826

Egawa et al (2018) Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma. PLoS One 13 e0198940 PMID: 29879220

If you know of a relevant reference for 6,8-Bis(benzylthio)octanoic acid, please let us know.

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关键词: 6,8-Bis(benzylthio)octanoic acid, 6,8-Bis(benzylthio)octanoic acid supplier, 6,8-Bis(benzylthio)octanoic, acid, CPI613, Pyruvate, dehydrogenase, PDH, a-ketoglutarate, alpha, KGDH, inhibitors, inhibits, antitumor, active, in, vivo, xenografts, cell, death, Other, Dehydrogenases, 5348, Tocris Bioscience

1 篇 6,8-Bis(benzylthio)octanoic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 6,8-Bis(benzylthio)octanoic acid 的部分引用包括：

Norbert et al (2020) Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing. Cell Rep 33 108411 PMID: 33238121

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