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6-Bnz-cAMP sodium salt

Cat. No. 5255 6 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cell permeable cAMP analog
化学名： N-Benzoyladenosine cyclic 3',5'-(hydrogen phosphate) monosodium salt
纯度： ≥98% (HPLC)
说明书
引用文献 (6)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 6-Bnz-cAMP sodium salt

6-Bnz-cAMP sodium salt is a cell permeable cAMP analog; selectively activates cAMP-dependent PKA but not Epac signaling pathways. Acts synergistically with 8-CPT-2Me-cAMP (Cat. No. 1645) to inhibit vascular smooth muscle cell proliferation.

技术数据 for 6-Bnz-cAMP sodium salt

分子量 455.29
公式 C17H15N5NaO7P
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1135306-29-4
PubChem ID 23672707
InChI Key SPYGSKQRPXISIB-FKVBDRBCSA-M
Smiles [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4NC(C5=CC=CC=C5)=O)[C@@H]2O)([H])CO1)2OP1(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 6-Bnz-cAMP sodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 45.53 100

制备储备液 for 6-Bnz-cAMP sodium salt

以下数据基于产品分子量 455.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.96 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for 6-Bnz-cAMP sodium salt

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for 6-Bnz-cAMP sodium salt

参考文献是支持产品生物活性的出版物。

Hewer et al (2011) PKA and Epac synergistically inhibit smooth muscle cell proliferation. J.Mol.Cell Cardiol. 50 87 PMID: 20971121

If you know of a relevant reference for 6-Bnz-cAMP sodium salt, please let us know.

按标靶查看相关产品

关键词: 6-Bnz-cAMP sodium salt, 6-Bnz-cAMP sodium salt supplier, Cell, permeable, cAMP, analog, PKA, Epac, vascular, smooth, muscle, cell, VSMC, 5255, Tocris Bioscience

6 篇 6-Bnz-cAMP sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 6-Bnz-cAMP sodium salt 的部分引用包括：

Marco et al (2021) A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression. Immunity 54 1665-1682.e14 PMID: 34129840

Caglar et al (2019) Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype. J Immunol 203 3247-3255 PMID: 31722989

Mishra et al (2018) Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming TAX Resistance in ER-positive Breast Cancer. Clin Cancer Res 24 1987 PMID: 29386221

Grant A et al (2020) Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. EMBO J 39 e105111 PMID: 32945574

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