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Submit Review6-Thioguanine
说明： Anticancer and immunosuppressive agent
别名： 6-TG
化学名： 2-Amino-6-mercaptopurine
纯度： ≥98% (HPLC)
生物活性 for 6-Thioguanine
6-Thioguanine is an anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).
技术数据 for 6-Thioguanine
| 分子量 | 167.19 |
| 公式 | C5H5N5S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 154-42-7 |
| PubChem ID | 2723601 |
| InChI Key | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| Smiles | NC1=NC(S)=C2C(NC=N2)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 6-Thioguanine
参考文献 for 6-Thioguanine
参考文献是支持产品生物活性的出版物。
Wang and Wang (2009) 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 48 2290 PMID: 19236003
Issaeva et al (2010) 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 70 6268 PMID: 20631063
Yuan et al (2011) 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res. 71 1904 PMID: 21239472
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关键词: 6-Thioguanine, 6-Thioguanine supplier, 6-TG, anticancer, chemotherapeutics, immunosupprressive, agents, cytotoxic, antineoplastic, cancer, BRCA2, tumors, epigenetics, antimetabolites, DNA, Methyltransferases, Immunosuppressants, Papain-like, Proteases, 4061, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Thioguanine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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The effects of 6-thioguanine on growth and metabolism.
By
Matthew Dempley on 12/02/2019
种属： Human
6-Thioguanine was incorporated into the RNA of all subcellular fractions, but to different extents and it also appears to be incorporated into a non-nucleotide fraction in the cell walk.
