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说明： ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
化学名： 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
纯度： ≥98% (HPLC)
生物活性 for 673 A
673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.
技术数据 for 673 A
| 分子量 | 223.28 |
| 公式 | C15H13NO |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 109437-62-9 |
| PubChem ID | 969428 |
| InChI Key | GSAVXYHVHQTGEA-UHFFFAOYSA-N |
| Smiles | O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 673 A
参考文献 for 673 A
参考文献是支持产品生物活性的出版物。
Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894
Raghavan et al (2017) Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 23 6934 PMID: 28814433
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