7-Chlorokynurenic acid sodium salt

Cat. No. 3697 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)

化学名： 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 7-Chlorokynurenic acid sodium salt

7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

技术数据 for 7-Chlorokynurenic acid sodium salt

分子量	245.59
公式	C₁₀H₅ClNNaO₃
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1263094-00-3
PubChem ID	52974249
InChI Key	IFZYIORLNGNLEI-UHFFFAOYSA-M
Smiles	[Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 7-Chlorokynurenic acid sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	24.56	100

制备储备液 for 7-Chlorokynurenic acid sodium salt

以下数据基于产品分子量 245.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.07 mL	20.36 mL	40.72 mL
5 mM	0.81 mL	4.07 mL	8.14 mL
10 mM	0.41 mL	2.04 mL	4.07 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

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产品说明书 for 7-Chlorokynurenic acid sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 7-Chlorokynurenic acid sodium salt

参考文献是支持产品生物活性的出版物。

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37 PMID: 7498252

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839 PMID: 9776380

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 85 6547

Donald et al (1988) Characterization of the [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P

If you know of a relevant reference for 7-Chlorokynurenic acid sodium salt, please let us know.

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关键词: 7-Chlorokynurenic acid sodium salt, 7-Chlorokynurenic acid sodium salt supplier, Potent, competitive, inhibitors, inhibits, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3697, Tocris Bioscience

2 篇 7-Chlorokynurenic acid sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 7-Chlorokynurenic acid sodium salt 的部分引用包括：

Jun Kyu et al (2021) Projection-dependent heterogeneity of cerebellar granule cell calcium responses. Mol Brain 14 63 PMID: 33789707

Roberto et al (2021) PSD-95 protects synapses from β-amyloid. Cell Rep 35 109194 PMID: 34077732

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