8-CPT-2Me-cAMP, sodium salt

Cat. No. 1645 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective Epac activator

化学名： 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt

纯度： ≥99% (HPLC)

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 8-CPT-2Me-cAMP, sodium salt

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC₅₀ = 2.2 μM), but not PKA (EC₅₀ > 10 μM). Stimulates Epac-mediated Ca²⁺-mediated Ca²⁺ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

许可信息

Sold with the permission of BioLog Life Science Institute

技术数据 for 8-CPT-2Me-cAMP, sodium salt

分子量	507.82
公式	C₁₇H₁₆ClN₅O₆PS.Na
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	634207-53-7
PubChem ID	16759604
InChI Key	VHTMKTNUXDACHB-KHXPSBENSA-M
Smiles	[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC)[C@@H](O2)N1C(SC2=CC=C(Cl)C=C2)=NC2=C1N=CN=C2N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 8-CPT-2Me-cAMP, sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	50.78	100

制备储备液 for 8-CPT-2Me-cAMP, sodium salt

以下数据基于产品分子量 507.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.85 mL	19.69 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
10 mM	0.2 mL	0.98 mL	1.97 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

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产品说明书 for 8-CPT-2Me-cAMP, sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 8-CPT-2Me-cAMP, sodium salt

参考文献是支持产品生物活性的出版物。

Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901 PMID: 12402047

Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca²⁺-induced Ca²⁺ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279 PMID: 12496249

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

If you know of a relevant reference for 8-CPT-2Me-cAMP, sodium salt, please let us know.

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关键词: 8-CPT-2Me-cAMP, sodium salt, 8-CPT-2Me-cAMP, sodium salt supplier, Selective, Epacs, epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase, EPAC, 1645, Tocris Bioscience

11 篇 8-CPT-2Me-cAMP, sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 8-CPT-2Me-cAMP, sodium salt 的部分引用包括：

Hu et al (2012) Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109 17681 PMID: 23045693

Soltoff and Hedden (2010) Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca²⁺]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem 285 13337 PMID: 20207737

Mohan et al (2015) Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Endocrinology 46 53 PMID: 25451967

Jeong et al (2007) IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 282 20752 PMID: 17517894

Garcia-Murillas et al (2014) An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene 33 2478 PMID: 23752180

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Hutchison and White (2015) Prostacyclin regulates bone growth via the Epac/Rap1 pathway. PLoS One 156 499 PMID: 25406016

Guichard et al (2013) Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 14 294 PMID: 24034615

Himer et al (2010) Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J 24 2631 PMID: 20371613

Scheibner et al (2009) The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol 40 251 PMID: 18703794

Ng (2018) Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal 51 59 PMID: 30076967

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