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Submit Review8-Hydroxy-DPAT hydrobromide
说明： Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
别名： 8-OH-DPAT hydrobromide
化学名： (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
纯度： ≥98% (HPLC)
生物活性 for 8-Hydroxy-DPAT hydrobromide
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.
R-enantiomer and 7-Hydroxy Isomer also available..
技术数据 for 8-Hydroxy-DPAT hydrobromide
| 分子量 | 328.29 |
| 公式 | C16H25NO.HBr |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 76135-31-4 |
| PubChem ID | 6917794 |
| InChI Key | BATPBOZTBNNDLN-UHFFFAOYSA-N |
| Smiles | Br.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 8-Hydroxy-DPAT hydrobromide
参考文献 for 8-Hydroxy-DPAT hydrobromide
参考文献是支持产品生物活性的出版物。
Helton and Colbert (1994) Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 46 902 PMID: 7897596
Middlemiss et al (1983) 8-OH-DPAT discriminates between subtypes of the 5HT1 recognition site. Eur.J.Pharmacol. 90 151 PMID: 6223827
Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT7 receptor. Eur.J.Pharmacol. 396 1 PMID: 10822046
Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865 PMID: 15050424
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关键词: 8-Hydroxy-DPAT hydrobromide, 8-Hydroxy-DPAT hydrobromide supplier, moderate, affinity, 5-HT7, 5-HT1A, agonists, Selective, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT1, 8-OH-DPAT, hydrobromide, 0529, Tocris Bioscience
28 篇 8-Hydroxy-DPAT hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 8-Hydroxy-DPAT hydrobromide 的部分引用包括：
Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517
Rock et al (2012) Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br J Pharmacol 165 2620 PMID: 21827451
Borroto-Escuela et al (2012) The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci 32 6295 PMID: 22553035
Ishima et al (2012) Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripipr. Transl Psychiatry 2 e170 PMID: 23047241
Manzke et al (2010) Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest 120 4118 PMID: 20978350
Hensler et al (2010) Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice. Psychoneuroendocrinology 35 469 PMID: 19766402
Rawls et al (2010) 5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144
Maciag et al (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development. Brain Res 1125 171 PMID: 17101120
McAllister et al (2014) GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus. Neuroendocrinology 100 228 PMID: 25402859
Bonchak et al (2014) Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin. Arch Biochem Biophys 563 71 PMID: 25132642
Duncan et al (2010) The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Pharmacol Exp Ther 31 1646 PMID: 20525077
Shelton et al (2015) Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci 8 453 PMID: 25642174
Khatri et al (2014) Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl) 231 1191 PMID: 23975037
Walory et al (2018) Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci 19 PMID: 30347827
Fuss et al (2013) Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running. Synapse 67 648 PMID: 23505009
Araragi et al (2013) Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Front Pharmacol 4 97 PMID: 23935583
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589 PMID: 19651659
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285
Pagano et al (2008) Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. J Neurosci 20 1190 PMID: 18407463
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
Richardson and Shelton (2015) N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Cell Signal 352 156 PMID: 25368340
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Invest Ophthalmol Vis Sci 3 e00103 PMID: 25692021
Tullis et al (2015) Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy. Eur J Neurosci 56 4560 PMID: 26200496
Rossi et al (2010) OE-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta. Psychoneuroendocrinology 35 1023 PMID: 20138435
Nguyen et al (2019) Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol 23 271 PMID: 31297011
Carvalho-Dias (2017) Serotonin regulates prostate growth through androgen receptor modulation. Sci Rep 7 15428 PMID: 29133842
Yin et al (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex 27 509 PMID: 26494800
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5-HT has a potential for relaxant.
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Anonymous on 02/18/2020
分析类型： In Vivo
种属： Rat
5-HT1A/7 receptor (8-OHDPAT)(0.1 lmol/L)
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