Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review9-Phenanthrol
说明： Selective TRPM4 blocker
化学名： 9-Hydroxyphenanthrene
生物活性 for 9-Phenanthrol
9-Phenanthrol is a selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
技术数据 for 9-Phenanthrol
| 分子量 | 194.23 |
| 公式 | C14H10O |
| 储存 | Store at +4°C |
| CAS Number | 484-17-3 |
| PubChem ID | 10229 |
| InChI Key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
| Smiles | OC2=CC1=C(C3=C2C=CC=C3)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 9-Phenanthrol
参考文献 for 9-Phenanthrol
参考文献是支持产品生物活性的出版物。
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105
按产品操作查看相关产品
关键词: 9-Phenanthrol, 9-Phenanthrol supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, TRPM, 4999, Tocris Bioscience
4 篇 9-Phenanthrol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 9-Phenanthrol 的部分引用包括：
Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052
Virginie et al (2021) Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice. Nat Commun 12 6815 PMID: 34819493
Lin et al (2017) Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex. Front Cell Neurosci 11 182 PMID: 28713246
O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations. J Neurosci 40 4813 PMID: 32414784
9-Phenanthrol 的评论
目前没有该产品的评论。 Be the first to review 9-Phenanthrol and earn rewards!
Have you used 9-Phenanthrol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image