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968

Cat. No. 5460 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Allosteric inhibitor of glutaminase
化学名： 5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 968

968 is an allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.

技术数据 for 968

分子量 475.42
公式 C27H27BrN2O
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 311795-38-7
PubChem ID 3099980
InChI Key NVFRRJQWRZFDLM-UHFFFAOYSA-N
Smiles BrC1=CC(C(C5=C4CC(C)(C)CC5=O)NC3=C4C2=CC=CC=C2C=C3)=CC=C1N(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 968

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.51 20

制备储备液 for 968

以下数据基于产品分子量 475.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.52 mL 52.59 mL 105.17 mL
1 mM 2.1 mL 10.52 mL 21.03 mL
2 mM 1.05 mL 5.26 mL 10.52 mL
10 mM 0.21 mL 1.05 mL 2.1 mL

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参考文献 for 968

参考文献是支持产品生物活性的出版物。

Wang et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18 207 PMID: 20832749

Stalnecker et al (2015) Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 112 394 PMID: 25548170

Lu et al (2010) Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 18 199 PMID: 20832746

If you know of a relevant reference for 968, please let us know.

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关键词: 968, 968 supplier, Hydrolases, allosteric, inhibitors, inhibits, glutaminase, oncogene, transformation, gls1, Glutaminase, 5460, Tocris Bioscience

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