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Submit ReviewA 205804
说明： Selective inhibitor of E-selectin and ICAM-1 expression
化学名： 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for A 205804
A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
技术数据 for A 205804
| 分子量 | 300.39 |
| 公式 | C15H12N2OS2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 251992-66-2 |
| PubChem ID | 9839311 |
| InChI Key | QQGWEXFLMJGCAL-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 205804
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 30.04 | 100 | |
| ethanol | 3 | 10 |
制备储备液 for A 205804
以下数据基于产品分子量 300.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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产品说明书 for A 205804
参考文献 for A 205804
参考文献是支持产品生物活性的出版物。
Stewart et al (2001) Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J.Med.Chem. 44 988 PMID: 11300880
Zhu et al (2001) Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J.Med.Chem. 44 3469 PMID: 11585452
Zhu et al (2002) Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. J.Org.Chem. 67 943 PMID: 11856042
If you know of a relevant reference for A 205804, please let us know.
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关键词: A 205804, A 205804 supplier, Selective, inhibitors, inhibits, E-selectin, ICAM-1, Adhesion, Molecules, A205804, Cell, Integrins, 2524, Tocris Bioscience
1 篇 A 205804 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 205804 的部分引用包括：
Othumpangat et al (2016) ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection. Virology 487 85 PMID: 26499045
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A 205804 的评论
平均评分: 5 (Based on 1 Review.)
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ICAM-1 inhibitor A 205804 show the highest increase in matrix copy number.
By
Anonymous on 10/20/2019
分析类型： In Vitro
种属： Human
细胞系/组织： HBEpC
We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A205804(TOCRIS),whereas 50ng/mL showed the highest(100%)increase in matrix copy number compared to the DMSO treatedcontrol cells infected with influenza virus
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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