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Submit ReviewA 331440 dihydrochloride
Discontinued Product
4697 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Selective H3 antagonist
化学名： 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for A 331440 dihydrochloride
A 331440 dihydrochloride is a high affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.
技术数据 for A 331440 dihydrochloride
| 分子量 | 422.39 |
| 公式 | C22H27N3O.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1049740-32-0 |
| PubChem ID | 16078942 |
| InChI Key | XFPYVTSGYYMTFS-GHVWMZMZSA-N |
| Smiles | CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 331440 dihydrochloride
参考文献 for A 331440 dihydrochloride
参考文献是支持产品生物活性的出版物。
Hancock et al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183 PMID: 15033391
Hancock et al (2004) In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144 PMID: 15447739
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关键词: A 331440 dihydrochloride, A 331440 dihydrochloride supplier, A331440, dihydrochloride, high, affinity, selective, histamine, histaminergic, H3, receptor, antagonists, anti-obesity, obese, Histamine, Receptors, 4697, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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