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Submit ReviewA 410099.1, amine
说明： Functionalized IAP ligand for PROTACs
化学名： tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride
纯度： ≥98% (HPLC)
生物活性 for A 410099.1, amine
A 410099.1, amine is a functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 4.6, 9.2 and 15.6 nM for cIAP1, cIAP2 and XIAP proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for A 410099.1, amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for A 410099.1, amine
| 分子量 | 620.22 |
| 公式 | C32H49N5O5.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2374122-37-7 |
| InChI Key | XWVNETXEAKCZET-CZNZTGDVSA-N |
| Smiles | C[C@@H](C(N[C@H](C(N1C[C@H](C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)N)=O)C4CCCCC4)=O)N(C(OC(C)(C)C)=O)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 410099.1, amine
参考文献 for A 410099.1, amine
参考文献是支持产品生物活性的出版物。
Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 14 342 PMID: 30807093
Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 10 886537 PMID: 35721509
If you know of a relevant reference for A 410099.1, amine, please let us know.
关键词: A 410099.1, amine, A 410099.1, amine supplier, A410099.1, amine, functionalized, boc, protected, E3, ligase, ligands, targeted, protein, degradation, building, blocks, components, TPD, degraders, PROTACs, IAP, inhibitor, of, apoptosis, XIAP, BIRC2, BIRC3, BIRC4, Functionalized, Ligase, Ligands, 6471, Tocris Bioscience
2 篇 A 410099.1, amine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 410099.1, amine 的部分引用包括：
Oskar et al (2018) Perfluorooctanoic acid (PFOA) exposure promotes proliferation, migration and invasion potential in human breast epithelial cells. Arch Toxicol 92 1729-1739 PMID: 29502166
Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 10 886537 PMID: 35721509
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia