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说明： Potent and selective CCK1 agonist; suppresses feeding
纯度： ≥95% (HPLC)
生物活性 for A-71623
A-71623 is a potent CCK1 agonist (IC50 = 3.7 nM) with 1200-fold selectivity over the CCK2 receptor. Suppresses food intake following central or peripheral administration.
技术数据 for A-71623
| 分子量 | 840.97 |
| 公式 | C44H56N8O9 |
| 序列 |
WKDF (Modifications: Trp-1 = Boc-Trp, Lys-2 = Lys(Tac), Phe-4 = N-methyl-Phe & C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 130408-77-4 |
| PubChem ID | 121964 |
| InChI Key | KNHCBYMGWWTGSO-ZYADHFCISA-N |
| Smiles | O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A-71623
| 溶解性 | Soluble to 1 mg/ml in 20mM PBS buffer |
产品说明书 for A-71623
参考文献 for A-71623
参考文献是支持产品生物活性的出版物。
Asin et al (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 42 699 PMID: 1513850
DeNinno et al (1990) Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem. 33 2951
Lin et al (1990) Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol. 39 346
If you know of a relevant reference for A-71623, please let us know.
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关键词: A-71623, A-71623 supplier, Potent, selective, CCK1, agonists, Suppresses, feeding, Cholecystokinin1, Receptors, A71623, Receptor, 2411, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.