A 779

Cat. No. 5937 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective Mas receptor (Ang-(1-7) receptor) antagonist

纯度： ≥95% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for A 779

A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT₁ or AT₂ receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

技术数据 for A 779

分子量	872.98
公式	C₃₉H₆₀N₁₂O₁₁
序列	DRVYIHA (Modifications: Ala-7 = D-Ala)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	159432-28-7
PubChem ID	10169886
InChI Key	GZSZZUXDAPDPOR-NGIFJXEWSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 779

溶解性	Soluble to 1 mg/ml in water

产品说明书 for A 779

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 779

参考文献是支持产品生物活性的出版物。

Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219 PMID: 25522140

Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433

Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293 PMID: 7850477

If you know of a relevant reference for A 779, please let us know.

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关键词: A 779, A 779 supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Other, Angiotensin, Receptors, 5937, Tocris Bioscience