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Submit ReviewA 80426 mesylate
Discontinued Product
2341 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
说明： High affinity α2 antagonist. Also 5-HT uptake inhibitor
化学名： N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate
纯度： ≥98% (HPLC)
生物活性 for A 80426 mesylate
A 80426 mesylate is a high affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
技术数据 for A 80426 mesylate
| 分子量 | 445.57 |
| 公式 | C23H27NO2.CH3SO3H |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 152148-64-6 |
| PubChem ID | 10366248 |
| InChI Key | RKQPEIGWZATOHW-FYZYNONXSA-N |
| Smiles | COC1=C2C([C@H](CN(CCC3=CC(OC=C4)=C4C=C3)C)CCC2)=CC=C1.CS(=O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 80426 mesylate
参考文献 for A 80426 mesylate
参考文献是支持产品生物活性的出版物。
Meyer et al (1995) Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition. Bioorg.Med.Chem.Letts. 5 2287
Giardina et al (1995) A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile. Drug Devel.Res. 35 246
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.