A 85380 dihydrochloride

Discontinued Product

5017 has been discontinued.

说明: High affinity and selective α4β2 nAChR agonist
化学名: 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride
纯度: ≥98% (HPLC)
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生物活性 for A 85380 dihydrochloride

A 85380 dihydrochloride is a high affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.

技术数据 for A 85380 dihydrochloride

分子量 237.13
公式 C9H12N2O.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 174740-86-4
PubChem ID 10399247
InChI Key GVEVDINKRFDXFP-JZGIKJSDSA-N
Smiles [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl

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参考文献 for A 85380 dihydrochloride

参考文献是支持产品生物活性的出版物。

Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405

Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981

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关键词: A 85380 dihydrochloride, A 85380 dihydrochloride supplier, A85380, dihydrochloride, high, affinity, selective, nicotinic, receptors, cholinergic, acetylcholine, alpha4beta2, a4b2, α4β2, agonists, Nicotinic, (a4b2), Receptors, 5017, Tocris Bioscience

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