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A 85380 dihydrochloride is a high affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.
分子量 | 237.13 |
公式 | C9H12N2O.2HCl |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 174740-86-4 |
PubChem ID | 10399247 |
InChI Key | GVEVDINKRFDXFP-JZGIKJSDSA-N |
Smiles | [C@@H]1(COC2=CC=CN=C2)CCN1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID: 8632405
Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID: 8887981
关键词: A 85380 dihydrochloride, A 85380 dihydrochloride supplier, A85380, dihydrochloride, high, affinity, selective, nicotinic, receptors, cholinergic, acetylcholine, alpha4beta2, a4b2, α4β2, agonists, Nicotinic, (a4b2), Receptors, 5017, Tocris Bioscience
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