A 943931 dihydrochloride

Name: A 943931 dihydrochloride
Brand: Tocris Bioscience
SKU: 3753

Cat. No. 3753 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3753 has been discontinued.

View all Histamine H<sub>4</sub> Receptors products.

说明： Potent and selective H₄ antagonist

化学名： 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for A 943931 dihydrochloride

A 943931 dihydrochloride is a potent and selective histamine H₄ receptor antagonist (pK_i values are 7.15 and 8.12 at human and rat receptors respectively). Blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models.

技术数据 for A 943931 dihydrochloride

分子量	368.31
公式	C₁₇H₂₁N₅.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1227675-50-4
PubChem ID	56972240
InChI Key	ISYUFRNZHUOGLA-CURYUGHLSA-N
Smiles	NC1=NC(N4C[C@H](N)CC4)=C2C(C(C=CC=C3)=C3CCC2)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for A 943931 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 943931 dihydrochloride

参考文献是支持产品生物活性的出版物。

Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H₄ receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547 PMID: 18817367

Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H₄ receptor. Br.J.Pharmacol. 157 14 PMID: 19413568

Aldi et al (2014) Histamine H4-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via PKC{epsilon}-Dependent Aldehyde Dehydrogenase Type-2 Activation. J.Pharmacol.Exp.Ther. 349 508 PMID: 24696042

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关键词: A 943931 dihydrochloride, A 943931 dihydrochloride supplier, A943931, potent, selective, H4, histamine, 4, antagonists, histaminergics, receptors, Histamine, Receptors, 3753, Tocris Bioscience

2 篇 A 943931 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 943931 dihydrochloride 的部分引用包括：

Yevgenia et al (2022) Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells. Elife 11 PMID: 35476632

Lenz et al (2018) Mast Cells in the Developing Brain Determine Adult Sexual Behavior. J Neurosci 38 8044 PMID: 30093566