α-Conotoxin AuIB

Name: α-Conotoxin AuIB
Brand: Tocris Bioscience
SKU: 3120
Rating: 5 (1 reviews)

Cat. No. 3120 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3120 has been discontinued.

View all Nicotinic Receptors (Other Subtypes) products.

说明： Selective α3β4 nAChR antagonist

纯度： ≥95% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for α-Conotoxin AuIB

α-Conotoxin AuIB is a selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

许可信息

Sold under license from University of Utah

技术数据 for α-Conotoxin AuIB

分子量	1572.76
公式	C₆₅H₈₉N₁₇O₂₁S₄
序列	GCCSYPPCFATNPDC (Modifications: Cys-15 = C-terminal amide, Disulfide bridges: 2-8, 3-15)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	216299-21-7
PubChem ID	73755065
InChI Key	SVNSCQIKKAACJG-SBLJLSJOSA-N
Smiles	C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)NC(=O)CN)C(=O)N[C@H](C(=O)N1)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)CO)C(=O)N)CC(=O)O)CC(=O)N)[C@@H](C)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for α-Conotoxin AuIB

分析证书/产品说明书

化学品安全技术说明书

参考文献 for α-Conotoxin AuIB

参考文献是支持产品生物活性的出版物。

Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked NE release. J.Neurosci. 18 8571 PMID: 9786965

Nai et al (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 63 311 PMID: 12527802

Park et al (2006) An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 452 775 PMID: 16715294

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关键词: alpha-Conotoxin AuIB, alpha-Conotoxin AuIB supplier, Selective, α3β4, alpha3β4, beta4, a3b4, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, AulB, a-conotoxin, conotoxins, venoms, (Other, Subtypes), 3120, Tocris Bioscience

篇 α-Conotoxin AuIB 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 α-Conotoxin AuIB 的引用文献。

α-Conotoxin AuIB 的评论

平均评分: 5 (Based on 1 Review.)

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Gold standard to compare analgesic drugs.

By Luiz Alexandre Magno on 02/17/2022

分析类型： In Vivo

种属： Rat

In our lab we used this product as a gold standard to compare analgesic effects of different toxins. It works very well in rodents.

Intrathecal administration works great

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.