Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewα-Conotoxin MII
Discontinued Product
1340 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
说明： Potent and selective α3β2 and β3 nAChR antagonist
纯度： ≥95% (HPLC)
生物活性 for α-Conotoxin MII
α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.
许可信息
Sold under license from the University of Utah.
技术数据 for α-Conotoxin MII
| 分子量 | 1710.99 |
| 公式 | C67H103N23O22S4 |
| 序列 |
GCCSNPVCHLEHSNLC (Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 175735-93-0 |
| PubChem ID | 57340508 |
| InChI Key | DUQYFGMBLOPGBY-XCQLYXDWSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for α-Conotoxin MII
参考文献 for α-Conotoxin MII
参考文献是支持产品生物活性的出版物。
Cartier et al (1996) A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 271 7522 PMID: 8631783
Harvey et al (1997) Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 51 336 PMID: 9203640
McIntosh et al (2000) Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 393 205 PMID: 10771014
David et al (2010) Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 31 978 PMID: 20377613
关键词: alpha-Conotoxin MII, alpha-Conotoxin MII supplier, Potent, α3β2, alpha3beta2, a3b2, b3, β3, beta3, subunit, selective, nicotinic, antagonist, Acetylcholine, ACh, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, MII, a-ConotoxinMII, venoms, Nicotinic, (Other, Subtypes), 1340, Tocris Bioscience
1 篇 α-Conotoxin MII 的引用文献
引用文献是使用了 Tocris 产品的出版物。 α-Conotoxin MII 的部分引用包括：
Krais et al (2011) CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis 32 1388 PMID: 21586512
α-Conotoxin MII 的评论
目前没有该产品的评论。 Be the first to review α-Conotoxin MII and earn rewards!
Have you used α-Conotoxin MII?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.