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Submit Reviewα-Conotoxin PIA
Discontinued Product
3121 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
说明： Selective antagonist of α6-containing nAChRs
生物活性 for α-Conotoxin PIA
α-Conotoxin PIA is a selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
许可信息
Sold under license from University of Utah
技术数据 for α-Conotoxin PIA
| 分子量 | 1981.3 |
| 公式 | C79H125N27O25S4 |
| 序列 |
RDPCCSNPVCTVHNPQIC (Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18) |
| 储存 | Store at -20°C |
| CAS Number | 669050-68-4 |
| PubChem ID | 90488800 |
| InChI Key | WINQUAHGULGZED-WAIIABLISA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for α-Conotoxin PIA
参考文献 for α-Conotoxin PIA
参考文献是支持产品生物活性的出版物。
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]DA release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087
Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990
关键词: alpha-Conotoxin PIA, alpha-Conotoxin PIA supplier, Selective, antagonists, a6, α6, alpha6, containing, nicotinic, receptors, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, PIA, a-ConotoxinPIA, conotoxins, venoms, Nicotinic, (Other, Subtypes), 3121, Tocris Bioscience
1 篇 α-Conotoxin PIA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 α-Conotoxin PIA 的部分引用包括：
Garção et al (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol 169 1600 PMID: 23638679
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.