α-Estradiol

Cat. No. 2823 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Endogenous estrogen receptor agonist

化学名： (17α)-Estra-1,3,5(10)-triene-3,17-diol

纯度： ≥97% (HPLC)

引用文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for α-Estradiol

α-Estradiol is an endogenous estrogen receptor ligand (K_i values are 0.2 and 1.2 nM for ERα and ERβ receptors respectively).

β-Estradiol also available.

技术数据 for α-Estradiol

分子量	272.38
公式	C₁₈H₂₄O₂
储存	Store at RT
纯度	≥97% (HPLC)
CAS Number	57-91-0
PubChem ID	68570
InChI Key	VOXZDWNPVJITMN-SFFUCWETSA-N
Smiles	[H][C@@]23CCC1=CC(O)=CC=C1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@H]4O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for α-Estradiol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	27.24	100
	ethanol	27.24	100

制备储备液 for α-Estradiol

以下数据基于产品分子量 272.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.67 mL	18.36 mL	36.71 mL
5 mM	0.73 mL	3.67 mL	7.34 mL
10 mM	0.37 mL	1.84 mL	3.67 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

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产品说明书 for α-Estradiol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for α-Estradiol

参考文献是支持产品生物活性的出版物。

Kuiper et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138 863 PMID: 9048584

Toran-Allerand et al (2002) ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. J.Neurosci. 22 8391 PMID: 12351713

If you know of a relevant reference for α-Estradiol, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: alpha-Estradiol, alpha-Estradiol supplier, Endogenous, estrogen, receptor, agonists, ER, Estrogen, Receptors, α-Estradiol, alpha-Estradiol, a-estradiol, and, Related, 2823, Tocris Bioscience

3 篇 α-Estradiol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 α-Estradiol 的部分引用包括：

McIsaac et al (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23 2993 PMID: 22696683

Dexter et al (2015) Robust network structure of the Sln1-Ypd1-Ssk1 three-component phospho-relay prevents unintended activation of the HOG MAPK pathway in Saccharomyces cerevisiae. Sci Rep 9 17 PMID: 25888817

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

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Pathways for α-Estradiol

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.