Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAACOCF3
说明： Phospholipase A2 inhibitor
别名： Arachidonyl trifluoromethyl ketone
化学名： 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
生物活性 for AACOCF3
AACOCF3 is a inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.
技术数据 for AACOCF3
| 分子量 | 356.47 |
| 公式 | C21H31F3O |
| 储存 | Store at -20°C |
| CAS Number | 149301-79-1 |
| PubChem ID | 5280436 |
| InChI Key | PLWROONZUDKYKG-DOFZRALJSA-N |
| Smiles | O=C(C(F)(F)F)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AACOCF3
| 溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml) |
产品说明书 for AACOCF3
参考文献 for AACOCF3
参考文献是支持产品生物活性的出版物。
Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937 PMID: 8083191
Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167 PMID: 19059366
Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619 PMID: 8195210
If you know of a relevant reference for AACOCF3, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: AACOCF3, AACOCF3 supplier, FAAH, inhibitors, inhibits, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors, Arachidonyl, trifluoromethyl, ketone, Other, Hydrolase, (FAAH), 1462, Tocris Bioscience
5 篇 AACOCF3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AACOCF3 的部分引用包括：
Schattauer et al (2017) Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase. Nat Commun 8 743 PMID: 28963507
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
Bianca et al (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110 15812 PMID: 24019484
Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Int J Obes (Lond) 35 4552 PMID: 25788673
Wang et al (2016) The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. PLoS Pathog. 12 e1005803 PMID: 27482714
您是否知道使用了 Tocris AACOCF3 的优秀论文？ 请告知我们.
AACOCF3 的评论
平均评分: 5 (Based on 1 Review.)
Have you used AACOCF3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
used this drug as an inhibitor.
By
Eric Wang on 10/05/2017
分析类型： In Vitro
种属： Mouse
细胞系/组织： macrophages
Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
