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Submit ReviewABT 089 dihydrochloride
说明： High affinity and selective α4β2 nAChR partial agonist
化学名： 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for ABT 089 dihydrochloride
ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.
技术数据 for ABT 089 dihydrochloride
| 分子量 | 265.18 |
| 公式 | C11H16N2O.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 161416-61-1 |
| PubChem ID | 23729426 |
| InChI Key | UGVSESCRKJTJAK-XRIOVQLTSA-N |
| Smiles | CC1=NC=CC=C1OC[C@H]2NCCC2.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ABT 089 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 26.52 | 100 | |
| DMSO | 5.3 | 20 |
制备储备液 for ABT 089 dihydrochloride
以下数据基于产品分子量 265.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.86 mL | 37.71 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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产品说明书 for ABT 089 dihydrochloride
参考文献 for ABT 089 dihydrochloride
参考文献是支持产品生物活性的出版物。
Rueter et al (2004) ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders. CNS Drug Rev. 10 167 PMID: 15179445
Sullivan et al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J.Pharmacol.Exp.Ther. 283 235 PMID: 9336329
Decker et al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. J.Pharmacol.Exp.Ther. 283 247 PMID: 9336330
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