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说明： Cytochrome P450 inhibitor; inhibits 20-HETE synthesis
化学名： 1H-Benzotriazol-1-amine
纯度： ≥98% (HPLC)
生物活性 for ABT
ABT is a cytochrome P450 inhibitor. Inhibits synthesis of the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE). Reduces intimal hyperplasia and vascular remodeling following endothelial injury in rat carotid arteries.
技术数据 for ABT
| 分子量 | 134.14 |
| 公式 | C6H6N4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1614-12-6 |
| PubChem ID | 1367 |
| InChI Key | JCXKHYLLVKZPKE-UHFFFAOYSA-N |
| Smiles | NN2C1=CC=CC=C1N=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ABT
参考文献 for ABT
参考文献是支持产品生物活性的出版物。
Mathews et al (1985) Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole. J.Pharmacol.Exp.Ther. 235 186 PMID: 4045721
Orozco et al (2013) 20-hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. J.Pharmacol.Exp.Ther. 346 67 PMID: 23658377
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关键词: ABT, ABT supplier, cytochrome, p450, inhibitors, inhibits, cyp450, synthesis, 20-HETE, Cytochrome, P450, 5038, Tocris Bioscience
1 篇 ABT 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ABT 的部分引用包括：
Zhu and Gomez (2012) Further evidence for the role of IP 3R 1 in regulating subsynaptic gene expression and neuromuscular transmission. Pharmacol Res Perspect 6 65 PMID: 22418950
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