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ABX 464

Cat. No. 6460 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： HIV RNA splicing modulator
化学名： 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ABX 464

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.

技术数据 for ABX 464

分子量 338.71
公式 C16H10ClF3N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1258453-75-6
PubChem ID 49846599
InChI Key OZOGDCZJYVSUBR-UHFFFAOYSA-N
Smiles FC(F)(F)OC1=CC=C(C=C1)NC=2N=C3C(Cl)=CC=CC3=CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ABX 464

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.87 100
ethanol 33.87 100

制备储备液 for ABX 464

以下数据基于产品分子量 338.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.76 mL 29.52 mL
5 mM 0.59 mL 2.95 mL 5.9 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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参考文献 for ABX 464

参考文献是支持产品生物活性的出版物。

Campos et al (2015) Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology 12 30 PMID: 25889234

Vautrin et al (2018) Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing. Sci.Rep. 9 792 PMID: 30692590

If you know of a relevant reference for ABX 464, please let us know.

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关键词: ABX 464, ABX 464 supplier, ABX464, HIV, RNA, splicing, regulators, modulators, CBC, cap, binding, complex, microRNA, miR-124, DNA,, and, Protein, Synthesis, 6460, Tocris Bioscience

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