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Submit ReviewAC 55649
说明： Selective RARβ2 agonist
化学名： 4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
纯度： ≥99% (HPLC)
生物活性 for AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
技术数据 for AC 55649
| 分子量 | 310.44 |
| 公式 | C21H26O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 59662-49-6 |
| PubChem ID | 1714884 |
| InChI Key | HXBKPYIEQLLNBK-UHFFFAOYSA-N |
| Smiles | CCCCCCCCC1=CC=C(C=C1)C1=CC=C(C=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AC 55649
参考文献 for AC 55649
参考文献是支持产品生物活性的出版物。
Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793
Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 52 1540 PMID: 19239230
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关键词: AC 55649, AC 55649 supplier, Selective, RARβ, RARbeta2, agonists, RAMBA, Retinoic, Acid, Receptors, AC55649, 2436, Tocris Bioscience
5 篇 AC 55649 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AC 55649 的部分引用包括：
Tay et al (2010) A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. Mol Pharmacol 77 218 PMID: 19884280
Kang et al (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Front Behav Neurosci 4 66 PMID: 20664575
Shrestha et al (2017) Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun 8 150 PMID: 28751710
Lee et al (2017) Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell 21 179 PMID: 28777944
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.