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Submit ReviewAc-RYYRIK-NH2
说明： High affinity NOP ligand
生物活性 for Ac-RYYRIK-NH2
Ac-RYYRIK-NH2 is a high affinity ligand for the NOP site (Ki = 1.5 nM). Antagonizes nociceptin-stimulated GTP binding in rat brain and the chronotropic effect of nociceptin on rat cardiomyocytes. However, displays potent agonist properties in vivo, inhibiting locomotor activity in mice.
技术数据 for Ac-RYYRIK-NH2
| 分子量 | 939.12 |
| 公式 | C44H70N14O9 |
| 序列 |
RYYRIK (Modifications: Arg-1 = N-terminal Ac, Lys-6 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 200959-48-4 |
| PubChem ID | 9963005 |
| InChI Key | WBBBVZGQADABSU-RERZDIOCSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ac-RYYRIK-NH2
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参考文献 for Ac-RYYRIK-NH2
参考文献是支持产品生物活性的出版物。
Berger et al (1999) Antagonism by acetyl-RYYRIK-NH2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br.J.Pharmacol. 126 555 PMID: 10188961
Berger et al (1999) Acetyl-RYYRIK-NH2, a nociceptin/orphanin FQ (noc/OFQ) receptor ligand, exhibits properties of an antagonist and agonist as well. Regul.Pept. 80 122 PMID: 10998548
Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393
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关键词: Ac-RYYRIK-NH2, Ac-RYYRIK-NH2 supplier, High, affinity, NOP, ligands, Nociceptin, Receptors, ORL1, OP4, Opioid, 1239, Tocris Bioscience
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