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说明： Potent, selective NOP partial agonist peptide
生物活性 for Ac-RYYRWK-NH2
Ac-RYYRWK-NH2 is a potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.
技术数据 for Ac-RYYRWK-NH2
| 分子量 | 1012.17 |
| 公式 | C49H69N15O9 |
| 序列 |
RYYRWK (Modifications: Arg-1 = C-terminal Ac, Lys-6 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 200959-47-3 |
| PubChem ID | 9811889 |
| InChI Key | YROQVQIJRORFAZ-SKGSPYGFSA-N |
| Smiles | CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ac-RYYRWK-NH2
参考文献 for Ac-RYYRWK-NH2
参考文献是支持产品生物活性的出版物。
Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393
Ho et al (2000) Characterization of the ORL1 receptor on adrenergic nerve in the rat anococcygeus. Br.J.Pharmacol. 131 349 PMID: 10991930
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关键词: Ac-RYYRWK-NH2, Ac-RYYRWK-NH2 supplier, Potent, selective, NOP, partial, agonists, peptide, Nociceptin, Receptors, ORL1, OP4, Opioid, 1387, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.