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Discontinued Product
2254 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Selective mGlu5 antagonist
化学名： 3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for ACDPP hydrochloride
Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM.
技术数据 for ACDPP hydrochloride
| 分子量 | 329.19 |
| 公式 | C12H13ClN6O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| PubChem ID | 16759168 |
| InChI Key | CXIHLPLRTFPHKX-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)C1=C(Cl)N=C(C(=O)NC2=CN=CC=C2)C(N)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ACDPP hydrochloride
参考文献 for ACDPP hydrochloride
参考文献是支持产品生物活性的出版物。
Bonnefous et al (2005) Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 15 1197 PMID: 15686941
Wang et al (2008) Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 28 4385 PMID: 18434517
关键词: ACDPP hydrochloride, ACDPP hydrochloride supplier, Selective, mGlu5, mGluR5, receptor, antagonists, mGlur, Group, I, Receptors, Glutamate, Metabotropic, 37804-11-8, 1224196-38-6, (Metabotropic), 2254, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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