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Discontinued Product
1111 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Group III mGlu agonist
化学名： (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
生物活性 for ACPT-I
ACPT-I is a agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.
许可信息
Sold with the permission of the CNRS
技术数据 for ACPT-I
| 分子量 | 217.18 |
| 公式 | C8H11NO6 |
| 储存 | Desiccate at -20°C |
| CAS Number | 194918-76-8 |
| PubChem ID | 4302960 |
| InChI Key | JARNORYOPMINDY-UHFFFAOYSA-N |
| Smiles | N[C@]1([C@](O)=O)C[C@@H]([C@](O)=O)[C@@H]([C@@](O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ACPT-I
参考文献 for ACPT-I
参考文献是支持产品生物活性的出版物。
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Chapman et al (2001) Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107 PMID: 11476756
De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17 PMID: 10771029
关键词: ACPT-I, ACPT-I supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, (Metabotropic), 1111, Tocris Bioscience
1 篇 ACPT-I 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ACPT-I 的部分引用包括：
Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99 PMID: 24402869
ACPT-I 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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