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Discontinued Product
1112 has been discontinued.
View all Non-selective Metabotropic Glutamate products.
说明： Competitive mGlu receptor antagonist
化学名： (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
生物活性 for ACPT-II
ACPT-II is a competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).
许可信息
Sold with the permission of the CNRS
技术数据 for ACPT-II
| 分子量 | 217.18 |
| 公式 | C8H11NO6 |
| 储存 | Desiccate at -20°C |
| CAS Number | 195209-04-2 |
| PubChem ID | 6604820 |
| InChI Key | FERIKTBTNCSGJS-OBLUMXEWSA-N |
| Smiles | N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ACPT-II
参考文献 for ACPT-II
参考文献是支持产品生物活性的出版物。
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676
Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600
关键词: ACPT-II, ACPT-II supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, 1112, Tocris Bioscience
2 篇 ACPT-II 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ACPT-II 的部分引用包括：
Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Mol Sci 97 11593 PMID: 11016958
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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