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Submit ReviewACV 1
Discontinued Product
3205 has been discontinued.
View all Nicotinic Receptors (Other Subtypes) products.
说明： α9α10-selective antagonist
别名： Conotoxin Vc1.1
生物活性 for ACV 1
Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.
许可信息
Sold under license from Dr Bruce Livett
技术数据 for ACV 1
| 分子量 | 1806.98 |
| 公式 | C71H103N23O25S4 |
| 序列 |
GCCSDPRCNYDHPEIC (Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16) |
| 储存 | Store at -20°C |
| CAS Number | 740980-24-9 |
| PubChem ID | 76321093 |
| InChI Key | KJQOYUHYAZGPIZ-PIJHVLQJSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ACV 1
参考文献 for ACV 1
参考文献是支持产品生物活性的出版物。
Sandall et al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904 PMID: 12779345
Nevin et al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406 PMID: 17804600
Halai et al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275 PMID: 19447885
Vincler et al (2006) Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc.Nat.Acad.Sci.USA 103 17880
关键词: ACV 1, ACV 1 supplier, α9α10, alpha9alpha10, selective, a9, a10, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, ACV1, ConotoxinVc11, venoms, Conotoxin, Vc1.1, (Other, Subtypes), 3205, Tocris Bioscience
1 篇 ACV 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ACV 1 的部分引用包括：
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.