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Adaptaquin

Cat. No. 5953 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
化学名： 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Adaptaquin

Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.

技术数据 for Adaptaquin

分子量 377.82
公式 C21H16ClN3O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 385786-48-1
PubChem ID 3740671
InChI Key KKYHNYRUBSYTCZ-UHFFFAOYSA-N
Smiles OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Adaptaquin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.78 100

制备储备液 for Adaptaquin

以下数据基于产品分子量 377.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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参考文献 for Adaptaquin

参考文献是支持产品生物活性的出版物。

Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29 PMID: 26936506

Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214 PMID: 27148687

If you know of a relevant reference for Adaptaquin, please let us know.

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关键词: Adaptaquin, Adaptaquin supplier, HIF-PHD, inhibitors, hypoxia, inducible, factor, prolyl, hydroxylases, inhibits, antioxidant, neuroprotective, brain, penetrant., Hypoxia, Inducible, Factors, Hydroxylases, 5953, Tocris Bioscience

1 篇 Adaptaquin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Adaptaquin 的部分引用包括：

Saravanan S et al (2021) HIF1α stabilization in hypoxia is not oxidant-initiated. Elife 10 PMID: 34596045

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