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Adenine

Cat. No. 4202 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Adenine receptor agonist
化学名： 6-Aminopurine hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Adenine

Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).

技术数据 for Adenine

分子量 171.59
公式 C5H5N5.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 2922-28-3
PubChem ID 76219
InChI Key UQVDQSWZQXDUJB-UHFFFAOYSA-N
Smiles NC1=C2C(NC=N2)=NC=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Adenine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 17.16 100
DMSO 17.16 100

制备储备液 for Adenine

以下数据基于产品分子量 171.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.83 mL 29.14 mL 58.28 mL
5 mM 1.17 mL 5.83 mL 11.66 mL
10 mM 0.58 mL 2.91 mL 5.83 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

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参考文献 for Adenine

参考文献是支持产品生物活性的出版物。

Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955 PMID: 15604413

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573

If you know of a relevant reference for Adenine, please let us know.

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关键词: Adenine, Adenine supplier, p0, receptors, agonists, purinergic, signaling, signalling, Adenine, Receptor, 4202, Tocris Bioscience

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该领域的文献

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P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.