ADU-S100 disodium salt

Cat. No. 7706 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： STING agonist

化学名： [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ADU-S100 disodium salt

ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.

技术数据 for ADU-S100 disodium salt

分子量	734.5
公式	C₂₀H₂₂N₁₀Na₂O₁₀P₂S₂
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1638750-95-4
PubChem ID	135390762
InChI Key	GDWOOOCBNOMMTL-ITQXCAEYSA-L
Smiles	O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)O[C@]1([H])CO[P@@]([S-])(O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@@]([S-])(O2)=O)=O.[Na+].[Na+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ADU-S100 disodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	3.67	5

制备储备液 for ADU-S100 disodium salt

以下数据基于产品分子量 734.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.05 mM	27.23 mL	136.15 mL	272.29 mL
0.25 mM	5.45 mL	27.23 mL	54.46 mL
0.5 mM	2.72 mL	13.61 mL	27.23 mL
2.5 mM	0.54 mL	2.72 mL	5.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for ADU-S100 disodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ADU-S100 disodium salt

参考文献是支持产品生物活性的出版物。

Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818

Zaidi et al (2021) Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 12 292 PMID: 33659041

If you know of a relevant reference for ADU-S100 disodium salt, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 STING-Dependent Signaling Agonists

关键词: ADU-S100 disodium salt, ADU-S100 disodium salt supplier, STING, agonist, agonism, apoptosis, signaling, cancer, in, vivo, T-cells, immunity, antitumor, CD8+, STING-Dependent, Signaling, 7706, Tocris Bioscience

篇 ADU-S100 disodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 ADU-S100 disodium salt 的引用文献。您是否知道使用了 Tocris ADU-S100 disodium salt 的优秀论文？请告知我们.