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AF-DX 384

Cat. No. 1345 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent M2/M4 antagonist
化学名： N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AF-DX 384

AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

技术数据 for AF-DX 384

分子量 478.64
公式 C27H38N6O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 118290-26-9
PubChem ID 119357
InChI Key MZDYABXXPZNUCT-UHFFFAOYSA-N
Smiles CCCN(CCC)CC1CCCCN1CCNC(=O)N1C2=C(C=CC=C2)C(=O)NC2=C1N=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AF-DX 384

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.93 50
ethanol 4.79 10

制备储备液 for AF-DX 384

以下数据基于产品分子量 478.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.89 mL 41.79 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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产品说明书 for AF-DX 384

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for AF-DX 384

参考文献是支持产品生物活性的出版物。

Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562 PMID: 7616446

Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283 PMID: 19111597

Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601 PMID: 1941609

If you know of a relevant reference for AF-DX 384, please let us know.

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关键词: AF-DX 384, AF-DX 384 supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384, M2, 1345, Tocris Bioscience

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