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说明： Progesterone receptor membrane component 1 (Pgrmc1) ligand
化学名： cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone
纯度： ≥97% (HPLC)
生物活性 for AG 205
AG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro.
技术数据 for AG 205
| 分子量 | 454.98 |
| 公式 | C22H23ClN6OS |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 442656-02-2 |
| PubChem ID | 4240652 |
| InChI Key | GJNBAISSZRNGTM-UHFFFAOYSA-N |
| Smiles | [H][C@@]12CCN(C)C[C@]1([H])C1=CC(C)=CC=C1N2C(=O)CSC1=NN=NN1C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AG 205
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 22.75 | 50 |
制备储备液 for AG 205
以下数据基于产品分子量 454.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.4 mL | 21.98 mL | 43.96 mL |
| 2.5 mM | 0.88 mL | 4.4 mL | 8.79 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
| 25 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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产品说明书 for AG 205
参考文献 for AG 205
参考文献是支持产品生物活性的出版物。
Ahmed et al (2010) Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. J.Pharmacol.Exp.Ther. 333 564 PMID: 20164297
Bashour and Wray (2012) Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1. Endocrinology. 153 4457 PMID: 22822163
Yoshitani et al (2005) A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements. Proteomics. 5 1472 PMID: 15798990
If you know of a relevant reference for AG 205, please let us know.
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关键词: AG 205, AG 205 supplier, AG205, progesterone, receptor, membrane, component, 1, Pgrmc1, ligands, inhibitors, inhibits, Progesterone, Receptor, 6242, Tocris Bioscience
2 篇 AG 205 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AG 205 的部分引用包括：
Leena et al (2021) PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Nat Commun 12 5991 PMID: 34645803
Matthias et al (2021) The PGRMC1 Antagonist AG-205 Inhibits Synthesis of Galactosylceramide and Sulfatide. Cells 10 PMID: 34944026
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